Recombinant Enzyme
by Artisan
A hard scar, fat that won't shift, skin that looks tired. The cause often sits under the surface, in tissue that has thickened, stored too much or held on to fluid.
Recombinant enzymes break down exactly what is in excess, then let your skin rebuild itself. Each enzyme acts on one target only, so the tissue around it is left alone.
Three enzymes. One job each.
Enzymes are natural proteins that break down specific substances in the body. "Recombinant" means they are made in a laboratory using biotechnology, not taken from animal sources. That makes them highly purified, consistent from batch to batch and precise in what they act on.
Each enzyme fits one target, like a key that opens a single lock.
Softens excess, hardened collagen. For scars, fibrosis, lumps and uneven texture.
Breaks down stored fat. For a double chin, jowls and stubborn body fat.
Disperses trapped fluid and opens the tissue so the other two spread evenly.
Some formulations also contain high molecular weight hyaluronic acid to hydrate and support the skin.
Clear what's in excess. Then let skin rebuild.
The treatment remodels tissue through natural processes, rather than through heat, inflammation or destroying cells.
Before
Thick, tangled collagen pulls the surface uneven. Enlarged fat cells and trapped fluid add bulk and puffiness.
After
Excess is cleared and growth factors are released. Fresh, organised collagen and elastic fibres form over the following weeks.
Collagenase breaks down the thick collagen that makes scars raised, firm or tight.
Lipase breaks fat into smaller molecules that your body clears naturally.
Hyaluronidase disperses trapped fluid and helps the other enzymes reach their target.
The cleared matrix signals your skin to rebuild new collagen and elastic fibres.
One platform. Three strengths.
Your doctor chooses the strength and mix to match your concern, from fine facial work to scars and body contouring.
Face
- Mild jowls and jawline definition
- Double chin
- Under-eye puffiness
- Laxity, dullness and uneven texture
- Sun damage and pigmentation
Scars & texture
- Acne scars
- Surgical and post-burn scars
- Raised and keloid scars
- Stretch marks
- Hardness after surgery or liposuction
Body
- Stubborn fat on abdomen, arms, thighs and flanks
- Cellulite
- Loose skin on arms, abdomen and legs
Correcting other treatments
- Swelling or lumps after fillers
- Nodules and granulomas
Studied in over 20 clinical studies. Measured, not assumed.
Results come from published studies in Europe, Latin America and the Middle East, with no serious side effects reported when protocols were followed.
of patients had firmer body skin, and 84% had less fat, in an 18-patient study across 5 centres.
scars, raised, sunken and keloid, improved significantly from the first or second session across 10 clinics.
session improved facial skin quality in all 5 women studied, confirmed by skin biopsy at 45 days.
Individual results vary. Studies were supported by the manufacturer. Full references at the end of this page.
A short visit. Minimal downtime.
Your doctor examines the area, sometimes with ultrasound, and plans the strength, dose and number of sessions.
The skin is cleansed and a numbing cream is applied 20–30 minutes before treatment.
The enzymes are placed with fine needles or a blunt cannula. A session takes about [ ] minutes.
Mild swelling, redness or tenderness is normal and usually settles within 3–10 days.
Sessions
Aftercare
Precise by design. Assessed for you.
The treatment is performed only by qualified doctors. Because each enzyme acts on one target, it remodels tissue without the inflammation or cell destruction of some other fat and scar treatments.
Possible side effects
Usually mild, settling within 3–10 days.
- Tenderness, redness or swelling
- Bruising
- Mild flu-like discomfort
- Rarely, an allergic reaction
It may not suit you if you
- Are pregnant or breastfeeding
- Have an autoimmune or atopic condition, such as psoriasis
- Have known allergies, including to bee stings
- Have liver or kidney disease, a clotting disorder or uncontrolled diabetes
- Have an active skin infection in the area
- Had a vaccine in the last 21 days
Your doctor reviews your medical history and may do a patch test first.
Frequently asked questions
Most people feel only mild discomfort. A numbing cream is applied beforehand, and your doctor may add a local anaesthetic to the solution.
Many patients notice a change after the first session. Results keep improving over the following weeks as your skin rebuilds new collagen.
This varies from person to person and with the concern treated. A healthy lifestyle and stable weight help maintain your results, and your doctor may suggest a maintenance session.
Most people return to normal activities the same or next day. Avoid strenuous exercise for 24–48 hours.
Many fat-dissolving injections work by destroying fat cells, which causes inflammation. Recombinant enzymes break down their specific targets more gently and also remodel collagen, so one treatment can address fat, laxity and texture together.
Yes. It can be part of a wider plan with skin boosters, energy devices or fillers. Your doctor will space treatments safely, usually 4–6 weeks apart in the same area.
In some cases. Enzymes can help with swelling or lumps after fillers. Your doctor will assess this at consultation.
Find out if it's right for you.
Every face and body is different. Meet [doctor's name] to discuss your concerns and get a plan made for you.
Suitability and outcomes are assessed individually by a qualified doctor. Results vary between individuals.
References
- Giraldo Mesa JA et al. AboutOpen Dermatology. 2026;13:1–6.
- Giraldo Mesa JA et al. London J Med & Health Res. 2025;25(5):55–65.
- De Castro García MP, Muñoz Montaño JR. Dermatología CMQ. 2020;18(2):84–92.
- Jabbour R et al. Heliyon. 2024;10:1–7.
- Rivera Z et al. Medicina Estética (SEME). 2025;84(3):1–14.
- Toro A et al. London J Med & Health Res. 2024;24(6):1–12.
- López Gehrke I et al. Lat Am J Clin Sci Med Technol. 2024;6:47–55.
- Santaella-Sosa E et al. Acta Dermatovenerol APA. 2024;33:141–143.
- Castelanich DG et al. Cureus. 2024;16(11).
- Castelanich DG et al. Acta Dermatovenerol APA. 2025;34:75–77.
- Paris E, López-Berroa J. London J Med & Health Res. 2024;24(5).
- Balczun J, Ramirez N. PRIME Journal. 2025;15(1):42–45.
- Fierro-Arias L et al. Dermatol Rev Mex. 2017;61(3):206–219.
Individual results vary. This page is educational and is not a substitute for a medical consultation.
✔ Those with stubborn pockets of fat, such as a double chin or soft jawline, that don’t shift with diet and exercise
✔ Those whose skin is loose, dull or uneven and who want it to rebuild from within
✔ Those with acne, surgical or raised scars, or stretch marks, who want them softer and flatter
✔ Those who want to treat fat, laxity and texture together, not one concern at a time
✔ Those who prefer a treatment that works without destroying cells or triggering inflammation
✔ Those who want a non-surgical option and to be home the same day
At The Artisan Clinic, all our doctors are well-trained professionals.
We keep ourselves up to date with latest trends and updates in the Aesthetic medicine field by being constantly involve and participating in seminars and conferences around the world.
Our Medical Director, Dr. Isaac Wong is an international trainer, and is often invited to speak in international conferences.
All treatments by The Artisan Clinic doctors are carefully curated by our Medical Director, Dr. Isaac Wong.
Lift by tension, not volume
CellREDM is placed along the ligaments at the sides of the face. As your own fibroblasts redensify them with new collagen, they tighten and lift, and nothing is added where overfilling begins.
Built from your own collagen
The matrix replaces lost ECM directly, then your fibroblasts move in and regenerate it. The lift comes from structure, not water.
Collagen without the inflammation
Most collagen stimulators rely on a controlled inflammatory reaction. In studies, human ADM lowered inflammatory markers instead, which is why we reach for it on sensitive, easily flushed skin.
A natural, heart-shaped contour
Anchoring the sides keeps the face widest at the cheekbones and tapering to the chin, so expressions stay natural and the face doesn't widen or round.
Aging is inevitable but you can choose to age gracefully.
Naturally healthy skin
Enhance facial contours
Thicker, fuller hair
Restore youthful looks
Fair and dewy skin
Body slimming
Dr. Isaac Wong
Beauty Reborn At The Artisan Clinic Everyday
Dr Isaac Wong is the Founder and Medical Director of The Artisan Clinic, an international trainer in aesthetic medicine. Dr Isaac Wong's work in injectables, threadlifts, and energy-based devices has led to invitations as a speaker at global conferences and appointments as a regional trainer for some aesthetic brands.
